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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • SHR, Rat Strain
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Mammal
Preferred_Name
  • SHR, Rat Strain
UMLS_CUI
  • C1519142
Contributing_Source
  • CDISC
ALT_DEFINITION
  • The spontaneous hypertensive rat was derived by Okamoto at the Kyoto school of medicine (1963) from a cross between an outbred Wistar Kyoto male with a significant elevation of blood pressure and a female Wistar Kyoto with elevated blood pressure. SHR rats develop hypertension spontaneously without exception at the age of 7-15 weeks with a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974).CDISC
Legacy_Concept_Name
  • SHR_Rat_Strain
FULL_SYN
  • SHR, Rat StrainPTNCI
  • SHRPTCDISC
DEFINITION
  • SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974). There is a high incidence of cardiovascular disease (Okamoto et al 1973), but a low incidence of stroke which can be increased to about 30% with chronic stress (Yamori 1984).NCI
code
  • C14412
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