About: Lobaplatin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Lobaplatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Lobaplatin
PubMedID_Primary_Reference
  • 21034513
UMLS_CUI
  • C0165747
CAS_Registry
  • 135558-11-1
FDA_UNII_Code
  • OX5XK1JD8C
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that contains the metal platinum and may kill cancer cells by damaging their DNA and stopping them from dividing. It is a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41669
PDQ_Closed_Trial_Search_ID
  • 41669
Chemical_Formula
  • C6H14N2.C3H4O3.Pt
Legacy_Concept_Name
  • Lobaplatin
FULL_SYN
  • lobaplatinPTNCI-GLOSSCDR0000045385
  • 1,2-diammino-methy lcyclobutane-platinum (II) lactateSNNCI
  • D-19466CNNCI
  • LOBAPLATINPTFDAOX5XK1JD8C
  • LobaplatinPTNCI
DEFINITION
  • A third-generation, water-soluble platinum compound with potential antineoplastic activity. Lobaplatin forms highly reactive, charged, platinum complexes that bind to nucleophilic groups such as GC- and AG-rich sites in DNA, inducing intrastrand DNA cross-links. These cross-links will ultimately result in induction of apoptosis and cell growth inhibition. Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.NCI
code
  • C1434
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