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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rogletimide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Rogletimide
NSC_Code
  • 619778
UMLS_CUI
  • C0164550
CAS_Registry
  • 92788-10-8
FDA_UNII_Code
  • 14P4QR28QF
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41461
PDQ_Closed_Trial_Search_ID
  • 41461
Chemical_Formula
  • C12H14N2O2
Legacy_Concept_Name
  • Rogletimide
FULL_SYN
  • PyridoglutethimideSYDTPNSC0619778
  • RogletimidePTNCI
  • RogletimidePTDCP31687
  • PyridoglutethimideSYNCI
  • ROGLETIMIDEPTFDA14P4QR28QF
DEFINITION
  • An orally active aminoglutethimide derivative with potential antineoplastic activity. Rogletimide reversibly inhibits the activity of aromatase, a cytochrome P450 family enzyme found in many tissues and the key enzyme in the oxidative aromatization process of androgens to estrogens. In estrogen-dependent cancers, the inhibition of aromatase by this agent leads to a reduction in the synthesis of estrogen, thereby inhibiting estrogen-mediated signal transduction and consequently reducing tumor cell growth. In addition, rogletimide also inhibits enzymes that catalyzing conversion of cholesterol to corticosteroids.NCI
code
  • C1427
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