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AttributesValues
rdf:type
rdfs:label
  • PHD Finger
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • PHD Finger
UMLS_CUI
  • C1518791
Legacy_Concept_Name
  • PHD_Finger
FULL_SYN
  • PHD Finger MotifSYNCI
  • C4HC3 Zinc FingerSYNCI
  • PHD Finger DomainSYNCI
  • Plant Homeodomain (PHD) Type Zinc FingerSYNCI
  • PHD FingerPTNCI
  • PHD-FingerSYNCI
DEFINITION
  • A C4HC3 zinc-finger-like motif, the PHD finger is found in nuclear proteins thought involved in chromatin-mediated transcriptional regulation. Single or multiple fingers are found. A specific function is not yet known, but it could be involved in protein-protein interactions important for assembly/activity of multi-component transcriptional regulatory complexes. In CBP it is an integral part of the acetyltransferase enzymatic core domain and contributes to CBP transcriptional activity. PHD fingers fold into an interleaved Zn-finger chelating two Zn ions in an atypical cross-braced conformation also shared by the FYVE and RING fingers; the zinc sites are located at opposite ends of a beta-sheet. Surrounding loops vary significantly in length and sequence between these three domains. (NCI)NCI
code
  • C14098
is someValuesFrom of
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