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AttributesValues
rdf:type
rdfs:label
  • ARID Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • ARID Domain
UMLS_CUI
  • C1515859
Legacy_Concept_Name
  • ARID_Domain
FULL_SYN
  • ARID DomainPTNCI
  • BRIGHT DomainSYNCI
  • AT-Rich Interactive DomainSYNCI
  • AT-Rich Interaction DomainSYNCI
DEFINITION
  • The approximately 100-amino acid ARID (AT-Rich Interaction Domain) DNA-binding domain occurs in some transcriptional regulators (and perhaps modifiers of chromatin structure) involved in embryonic development, cell lineage, and cell cycle control. The domain shows more diversity in structure and function than the highly conserved sequence suggests: at least six alpha helices separated by beta-strands, loops, or turns. Although Bright, dead ringer, and MRF-2 preferentially bind to AT-rich sites, DNA binding of ARID-proteins is not necessarily sequence specific; ARID protein p270 of the SWI-SNF complex exhibits non-specific DNA binding activity. ARID family proteins may be involved in a wide range of DNA interactions. Inappropriate expression of ARID proteins is increasingly implicated in tumorigenesis.NCI
code
  • C14094
is someValuesFrom of
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