About: RHO Effector Domain     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • RHO Effector Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • RHO Effector Domain
UMLS_CUI
  • C1514650
Legacy_Concept_Name
  • RHO_Effector_Domain
FULL_SYN
  • RHO Effector DomainPTNCI
  • HR1 DomainSYNCI
  • REM RepeatSYNCI
  • Hr1 RepeatSYNCI
DEFINITION
  • The REM repeat, which is also called rho effector or HR1 domain, was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were later shown to bind the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal REM repeat complexed with RhoA has been determined by X-ray crystallography. It forms an antiparallel coiled-coil fold termed an ACC finger.NCIpfam.wustl.edu/cgi-bin/getdesc?name=HR1
code
  • C14078
is someValuesFrom of
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