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AttributesValues
rdf:type
rdfs:label
  • FHA Domain
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • FHA Domain
UMLS_CUI
  • C1517093
Legacy_Concept_Name
  • FHA_Domain
FULL_SYN
  • Forkhead-Associated DomainSYNCI
  • FHA DomainPTNCI
DEFINITION
  • The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognize phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded sandwich, which sometimes contain small helical insertions between the loops connecting the strands. To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not aracheal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes. DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.NCIfrom Pfam PF00498
code
  • C13945
is someValuesFrom of
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