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AttributesValues
rdf:type
rdfs:label
  • Fulvestrant
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Fulvestrant
NSC_Code
  • 719276
UMLS_CUI
  • C0935916
CAS_Registry
  • 129453-61-8
Accepted_Therapeutic_Use_For
  • Hormone receptor-positive metastatic breast cancer
In_Clinical_Trial_For
  • Breast cancer; Endometrial cancer; Prostate cancer
FDA_UNII_Code
  • 22X328QOC4
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat certain types of breast cancer in postmenopausal women. It is also being studied in the treatment of other types of cancer. Faslodex blocks estrogen activity in the body and is a type of antiestrogen.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43053
PDQ_Closed_Trial_Search_ID
  • 43053
Chemical_Formula
  • C32H47F5O3S
Legacy_Concept_Name
  • Fulvestrant
CHEBI_ID
  • CHEBI:31638
FULL_SYN
  • FulvestrantPTNCI
  • Faslodex(ICI 182,780)SYDTPNSC0719276
  • fulvestrantPTNCI-GLOSSCDR0000306498
  • FulvestrantPTDCP20048
  • ZD9238CNNCI
  • FaslodexPTNCI-GLOSSCDR0000415316
  • FaslodexBRNCI
  • ICI 182780PTNCI-GLOSSCDR0000045005
  • FULVESTRANTPTFDA22X328QOC4
  • 7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diolSNNCI
  • ICI 182,780CNNCI
DEFINITION
  • A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)NCI
code
  • C1379
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