About: Ring Finger Domain

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Ring Finger Domain
rdfs:subClassOf	Protein Binding Domain Metal Binding Site
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Ring Finger Domain
UMLS_CUI	C1521759
Legacy_Concept_Name	Ring_Finger_Domain
FULL_SYN	Ring FingerSYNCI Ring Finger MotifSYNCI Ring-Type Zinc Finger DomainSYNCI Ring Finger DomainPTNCI
DEFINITION	The RING finger is a specialized type of Zn-finger consisting of 40 to 60 residues, which has the consensus sequence CX2CX(9-39)CX(1-3)HX(2-3)C/HX2CX(4-48)CX2C, that binds two atoms of zinc, and is involved in mediating protein-protein interactions. The RING domain mediates the interaction with the appropriate E2 enzyme. Unlike HECT E3 enzymes that form a thiol-ester with ubiquitin, RING fingers likely mediate ubiquitination by facilitating the direct transfer of ubiquitin from E2 enzyme to lysine residues on the target substrate.NCI
code	C13746
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0508104
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