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AttributesValues
rdf:type
rdfs:label
  • Diaziquone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
  • Chemical Viewed Structurally
Preferred_Name
  • Diaziquone
NSC_Code
  • 182986
UMLS_CUI
  • C0113600
CAS_Registry
  • 57998-68-2
FDA_UNII_Code
  • FQL5EUP13W
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that is able to cross the blood-brain barrier and kill cancer cells in the central nervous system.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39161
PDQ_Closed_Trial_Search_ID
  • 39161
Chemical_Formula
  • C16H20N4O6
Legacy_Concept_Name
  • Diaziquone
FULL_SYN
  • AZQPTNCI-GLOSSCDR0000044389
  • AziridinylbenzoquinoneSYNCI
  • 1,4-cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl esterSNNCI
  • diaziquonePTNCI-GLOSSCDR0000045178
  • Aziridinyl BenzoquinoneSYNCI
  • 2,5-diaziridinyl-3,6-bis(ethoxycarbonyl-amino)-1,4-benzoquinoneSNNCI
  • Carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI)SYDTPNSC0182986
  • AZQABNCI
  • Aziridinylbenzoquinone carbamic acidSYNCI
  • [2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]biscarbamic acid diethyl esterSNNCI
  • CI-904CNNCI
  • 2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbamic acid diethyl esterSNNCI
  • 2,5-bis(1-aciridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinoneSNNCI
  • 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinoneSNNCI
  • 1,4-Cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl esterSYDTPNSC0182986
  • DIAZIQUONEPTFDAFQL5EUP13W
  • 1,4-cyclohexadiene-1,4-dicarbamic acid,2,5-bis(1-aziridinyl)-3,6-dioxo,-diethyl esterSNNCI
  • DiaziquoneSYDTPNSC0182986
  • carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI)SNNCI
  • DiaziquonePTNCI
DEFINITION
  • A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors.NCI
code
  • C1363
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