About: Cladribine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Cladribine
rdfs:subClassOf	Purine Antagonist Radiosensitizing Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Cladribine
NSC_Code	105014 105014-F
UMLS_CUI	C0092801
CAS_Registry	4291-63-8
Accepted_Therapeutic_Use_For	Acute myeloid leukemia; Chronic lymphocytic leukemia; Cutaneous T-cell lymphoma; Hairy cell leukemia; Langerhans cell histiocytosis; Non-Hodgkins lymphoma; Waldenstroms macroglobulinemia
In_Clinical_Trial_For	Chronic lymphocytic leukemia; Hairy cell leukemia
FDA_UNII_Code	47M74X9YT5
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of drugs called antimetabolites.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41184
PDQ_Closed_Trial_Search_ID	41184
Chemical_Formula	C10H12ClN5O3
Legacy_Concept_Name	Cladribine
CHEBI_ID	CHEBI:567361
FULL_SYN	2-ChlorodeoxyadenosineSNNCI cladribinePTNCI-GLOSSCDR0000045341 2-Chloro-2-DeoxyadenosineSNNCI CdAABNCI 2CDAABNCI 2-CdAABNCI LeustatFBNCI CLADRIBINEPTFDA47M74X9YT5 RWJ-26251CNNCI LeustatinBRNCI CladribinaSYNCI CladribinePTNCI LeustatineFBNCI
DEFINITION	A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)NCI
DesignNote	http://www.cancercare.on.ca/pdfdrugs/Cladribi.pdf
code	C1336
sameAs	CLADRIBINE CLADRIBINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0026332
is someValuesFrom of	nodeID://b651793 nodeID://b658869 nodeID://b660595 nodeID://b660596 nodeID://b660599 nodeID://b660601 nodeID://b660603
is sameAs of	CLADRIBINE CLADRIBINE CLADRIBINE

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