About: Helix-Turn-Helix Motif     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Helix-Turn-Helix Motif
rdfs:subClassOf
Semantic_Type
  • Amino Acid Sequence
Preferred_Name
  • Helix-Turn-Helix Motif
UMLS_CUI
  • C0282642
ALT_DEFINITION
  • The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)MSH2001
Legacy_Concept_Name
  • Helix-Turn-Helix_Motif
FULL_SYN
  • Helix-Turn-Helix MotifPTNCI
  • Helix-Turn-HelixSYNCI
  • HTH DNA Binding DomainSYNCI
DEFINITION
  • The first DNA-binding protein motif to be recognized. Originally identified in bacterial proteins and found in many DNA-binding proteins from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices.NCI
code
  • C13341
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