About: C2H2 Zinc Finger

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Attributes	Values
rdf:type	Class
rdfs:label	C2H2 Zinc Finger
rdfs:subClassOf	Zinc-Binding, DNA-Binding Motif
Semantic_Type	Amino Acid Sequence
Preferred_Name	C2H2 Zinc Finger
UMLS_CUI	C1511358
ALT_DEFINITION	Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.MSH2001
Legacy_Concept_Name	C2H2_Zinc_Finger
FULL_SYN	C2H2 Zinc FingerPTNCI
DEFINITION	One of three structural motifs observed in DNA binding domains of zinc proteins. Domains in DNA- and RNA-binding proteins that contain amino acids which are folded into a single structural unit around a zinc atom that links two cysteines and two histidines. Each finger is postulated to recognize a specific sequence of about five nucleotide pairs. Originally identified in the TFIIIA transcription factor, it is also known as the C2H2 zinc finger.NCI
code	C13294
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