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AttributesValues
rdf:type
rdfs:label
  • Leuprolide Acetate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Leuprolide Acetate
NSC_Code
  • 377526
UMLS_CUI
  • C0700596
CAS_Registry
  • 74381-53-6
Accepted_Therapeutic_Use_For
  • Endometriosis; In-vitro fertilization; Precocious puberty; Premenstrual syndrome; Prostate cancer; Uterine fibroid tumors
In_Clinical_Trial_For
  • Alzheimer disease; Prostate cancer
FDA_UNII_Code
  • 37JNS02E7V
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat symptoms of advanced prostate cancer. It is also being studied in the treatment of other conditions and types of cancer. The active ingredient leuprolide blocks the body from making testosterone (a male hormone) and estradiol (a female hormone). It may stop the growth of prostate cancer cells that need testosterone to grow. Some brands of leuprolide are also used to treat early puberty in children and certain gynecologic conditions. Leuprolide acetate is a type of gonadotropin-releasing hormone analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40058
PDQ_Closed_Trial_Search_ID
  • 40058
Chemical_Formula
  • C59H84N16O12.C2H4O2
Legacy_Concept_Name
  • Leuprolide
CHEBI_ID
  • CHEBI:63597
FULL_SYN
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) MonoacetateSNNCI
  • Abbott 43818CNNCI
  • Abbott-43818CNNCI
  • Depo-EligardFBNCI
  • Lucrin DepotFBNCI
  • Uno-EnantoneFBNCI
  • Enantone-GynFBNCI
  • Lupron DepotBRNCI
  • 6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig) MonoacetateSNNCI
  • leuprolide acetatePTNCI-GLOSSCDR0000595341
  • Leuprolide AcetatePTDCP31429
  • LEUPABNCI
  • Lupron Depot-PedBRNCI
  • ViadurPTNCI-GLOSSCDR0000595349
  • LupronPTNCI-GLOSSCDR0000595348
  • EligardPTNCI-GLOSSCDR0000595347
  • LucrinFBNCI
  • ViadurBRNCI
  • LupronBRNCI
  • A-43818CNNCI
  • TAP-144CNNCI
  • Leuprolide AcetatePTNCI
  • EnantonFBNCI
  • LeuplinFBNCI
  • ProcrenFBNCI
  • ProcrinFBNCI
  • ProstapFBNCI
  • LEUPROLIDE ACETATEPTFDA37JNS02E7V
  • Leuprorelin AcetateSYNCI
  • CarcinilFBNCI
  • GinecrinFBNCI
  • EnantoneFBNCI
  • Lupron Depot-3 MonthBRNCI
  • Lupron Depot-4 MonthBRNCI
  • TrenantoneFBNCI
DEFINITION
  • The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression.NCI
code
  • C1319
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