About: Tacrolimus

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Tacrolimus
rdfs:subClassOf	mTOR Inhibitors IMMUNE SUPPRESSANTS nodeID://b718858 nodeID://b718859 nodeID://b718860
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Tacrolimus
NSC_Code	717865
UMLS_CUI	C0085149
CAS_Registry	109581-93-3
Accepted_Therapeutic_Use_For	Atopic dermatitis; Kidney transplant rejection, prophylaxis; Liver transplant rejection, prophylaxis
In_Clinical_Trial_For	Graft versus Host Disease, prevention; Kidney transplantation rejection, prevention
FDA_UNII_Code	WM0HAQ4WNM
Contributing_Source	FDA
ALT_DEFINITION	A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42009
PDQ_Closed_Trial_Search_ID	42009
Chemical_Formula	C44H69NO12.H2O
Legacy_Concept_Name	Tacrolimus
CHEBI_ID	CHEBI:61057
FULL_SYN	tacrolimusPTNCI-GLOSSCDR0000045414 FK 506CNNCI Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetronePTDCP01195 PrografBRNCI TACROLIMUSPTFDAWM0HAQ4WNM Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetroneSNNCI ProtopicBRNCI TacrolimusSYDTPNSC0717865 FujimycinSYNCI TacrolimusPTNCI
DEFINITION	A macrolide isolated from Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent.NCI
code	C1311
sameAs	TACROLIMUS TACROLIMUS
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0025261
is someValuesFrom of	nodeID://b646313 nodeID://b646318 nodeID://b673591 nodeID://b680764 nodeID://b692921 nodeID://b692960 nodeID://b693000 nodeID://b694233 nodeID://b703964
is sameAs of	TACROLIMUS TACROLIMUS TACROLIMUS

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