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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Trichostatin A
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Trichostatin A
NSC_Code
  • 311042
UMLS_CUI
  • C0077063
CAS_Registry
  • 58880-19-6
FDA_UNII_Code
  • 3X2S926L3Z
Contributing_Source
  • FDA
Chemical_Formula
  • C17H22N2O3
Legacy_Concept_Name
  • Trichostatin_A
CHEBI_ID
  • CHEBI:46024
FULL_SYN
  • TRICHOSTATIN APTFDA3X2S926L3Z
  • Trichostatin APTNCI
  • Trichostatin ASYDTPNSC0311042
  • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamidePTDCP31914
  • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamideSNNCI
DEFINITION
  • A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals. (NCI04)NCI
code
  • C1261
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