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AttributesValues
rdf:type
rdfs:label
  • Triazinate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Triazinate
NSC_Code
  • 139105
UMLS_CUI
  • C0077008
CAS_Registry
  • 41191-04-2
FDA_UNII_Code
  • DD99Y262WC
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39162
PDQ_Closed_Trial_Search_ID
  • 39162
Legacy_Concept_Name
  • Triazinate
FULL_SYN
  • ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluorideSNNCI
  • benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-, monoethanesulfonate (9CI)SNNCI
  • Soluble Baker's AntifolSYNCI
  • Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (9CI)SYDTPNSC0127755
  • Bakers AntifolSYNCI
  • BAFABNCI
  • ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(9CI)SNNCI
  • TZTABNCI
  • Baker's AntifolSYNCI
  • Baker's AntifolSYDTPNSC0113423
  • Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (8CI)SYDTPNSC0127755
  • Bakers AntifolateSYNCI
  • Baker's Antifol solubleSYDTPNSC0139105
  • Ethanesulfonic Acid CompoundSYNCI
  • Baker's AntifolateSYNCI
  • TRIAZINATEPTFDADD99Y262WC
  • alpha-(2-chloro-4-(4,6-diamino-2,2-dimethyl-s-trizin-1(2H)-yl)phenoxy)-N,N-dimethyl-m-toluamide ethanesulfonic acidSNNCI
  • Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluorideSYDTPNSC0127755
  • Benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-, monoethanesulfonate (9CI)SYDTPNSC0127755
  • TriazinateSYDTPNSC0139105
  • ethanesulfonic acid compound with 3-((2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy)methyl)-N,N-dimethylben zamide (1:1)SNNCI
  • ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(8CI)SNNCI
  • TriazinatePTNCI
DEFINITION
  • A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI04)NCI
code
  • C1258
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