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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Miglustat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Miglustat
UMLS_CUI
  • C1321596
CAS_Registry
  • 72599-27-0
FDA_UNII_Code
  • ADN3S497AZ
Contributing_Source
  • FDA
Chemical_Formula
  • C10H21NO4
Legacy_Concept_Name
  • SC-48334
CHEBI_ID
  • CHEBI:50381
FULL_SYN
  • MiglustatPTDCP32222
  • N-Butyl DeoxynojirimycinSNNCI
  • 3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-,(2R-(2alpha,3beta,4alpha,5beta))-SNNCI
  • N-ButylmoranolineSYNCI
  • 1,5-(butylimino)-1,5-dideoxy-D-glucitolSNNCI
  • MIGLUSTATPTFDAADN3S497AZ
  • ZavescaBRNCI
  • SC 48334CNNCI
  • SC-48334CNNCI
  • MiglustatPTNCI
DEFINITION
  • A synthetic, N-alkylated imino analogue of D-glucose. Miglustat competitively and reversibly binds to and inhibits the activity of UDP-glucose ceramide glucosyltransferase, which catalyzes the initial step in the synthesis of glycosphingolipids (GSL). This leads to a decrease in the production of glycosphingolipid, which has important roles in various cellular processes. Miglustat can be used in substrate reduction therapy in diseases in which the enzyme glucocerebrosidase, that is responsible for the breakdown of GSL, is deficient.NCI
code
  • C1222
sameAs
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