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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sirolimus
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Sirolimus
NSC_Code
  • 226080
UMLS_CUI
  • C0072980
CAS_Registry
  • 53123-88-9
Accepted_Therapeutic_Use_For
  • Kidney transplant rejection, prevention
In_Clinical_Trial_For
  • Acute leukemia; Glioblastoma multiforme; Graft-versus-host disease; Kidney transplantation; Liver transplantation; Membranous glomerulonephritis; Multiple sclerosis; Non-Hodgkins lymphoma
FDA_UNII_Code
  • W36ZG6FT64
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42555
PDQ_Closed_Trial_Search_ID
  • 42555
Chemical_Formula
  • C51H79NO13
Legacy_Concept_Name
  • Sirolimus
CHEBI_ID
  • CHEBI:9168
FULL_SYN
  • SirolimusPTDCP20504
  • 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2SNNCI
  • RAPAABNCI
  • RAPAMYCINSYDTPNSC0226080
  • SIROLIMUSPTFDAW36ZG6FT64
  • AY 22989CNNCI
  • RapamunePTNCI-GLOSSCDR0000580375
  • RapamuneBRNCI
  • WY-090217CNNCI
  • RapamycinSYNCI
  • SirolimusPTNCI
  • SILA 9268ACNNCI
  • rapamycinPTNCI-GLOSSCDR0000285947
  • sirolimusPTNCI-GLOSSCDR0000045513
DEFINITION
  • A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)NCI
code
  • C1212
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