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AttributesValues
rdf:type
rdfs:label
  • Pyrazofurin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Pyrazofurin
NSC_Code
  • 143095
UMLS_CUI
  • C0072661
CAS_Registry
  • 30868-30-5
FDA_UNII_Code
  • 4B15044GQZ
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39575
PDQ_Closed_Trial_Search_ID
  • 39575
Chemical_Formula
  • C9H13N3O6
Legacy_Concept_Name
  • Pyrazofurin
FULL_SYN
  • PirazofurinSYDTPNSC0143095
  • PyrazomycinSYDTPNSC0143095
  • PirazofurinSYNCI
  • PyrazomycinSYNCI
  • PyrazofurinPTNCI
  • 47599SYDTPNSC0143095
  • 4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamideSNNCI
  • Compound 47599SYNCI
  • Pyrazole, -3-carboxamide, 4-hydroxy-5-.beta.-L-ribofuranosyl-SYDTPNSC0143095
  • 1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI)SYDTPNSC0143095
  • PRZFABNCI
  • 1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI)SNNCI
  • Beta-PyrazomycinSYNCI
  • 47599CNNCI
  • 4-Hydroxy-3-.beta.-D-ribofuranosylpyrazole-5-carboxamideSYDTPNSC0143095
  • Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosylSNNCI
  • PYRAZOFURINPTFDA4B15044GQZ
  • PYRAZOFURINSYDTPNSC0143095
  • .beta.-PyrazomycinSYDTPNSC0143095
DEFINITION
  • A nucleoside analog. Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04)NCI
code
  • C1208
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