About: Polysialic Acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Polysialic Acid
rdfs:subClassOf
Semantic_Type
  • Carbohydrate
Preferred_Name
  • Polysialic Acid
UMLS_CUI
  • C0071677
PDQ_Open_Trial_Search_ID
  • 37839
PDQ_Closed_Trial_Search_ID
  • 37839
Legacy_Concept_Name
  • Polysialic_Acid
CHEBI_ID
  • CHEBI:26206
FULL_SYN
  • Polysialic AcidPTNCI
DEFINITION
  • A highly negative-charged carbohydrate composed of a linear polymer of alpha 2,8-linked sialic acid residue with potential immunotherapeutic activity. Polysialic acid (PSA) is mainly attached to the neural cell adhesion molecule (NCAM), a membrane-bound glycoprotein overexpressed in certain types of cancers. In embryonic tissue PSA-NCAM is abundantly expressed and PSA plays an important role in formation and remodeling of the neural system through modulation of the adhesive properties of NCAM, thereby reducing cell-cell interactions and promoting cellular mobility. In adult tissue however, the expression of PSA-NCAM is associated with a variety of malignant tumors, signifying its potential role in tumor metastasis. When administered in a vaccine formulation, PSA may stimulate a cytotoxic T cell response against tumors expressing PSA, thereby resulting in a reduction in tumor size.NCI
code
  • C1201
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