About: Pegaspargase

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pegaspargase
rdfs:subClassOf	Protein Synthesis Inhibitor
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Pegaspargase
NSC_Code	624239 644954
UMLS_CUI	C0071568
CAS_Registry	130167-69-0
Accepted_Therapeutic_Use_For	Acute lymphoblastic leukemia
FDA_UNII_Code	7D96IR0PPM
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the drug asparaginase that is linked to a substance called PEG, which makes the drug stay in the body longer. Asparaginase is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	40312
PDQ_Closed_Trial_Search_ID	40312
Legacy_Concept_Name	Pegaspargase
FULL_SYN	PegaspargasePTNCI Polyethylene Glycol-L-AsparaginaseSYNCI (Monomethoxypolyethylene Glycol Succinimidyl)74-L-AsparaginaseSNNCI Polyethylene Glycol L-AsparaginaseSYDTPNSC0624239 pegaspargasePTNCI-GLOSSCDR0000045292 PEG-AsparaginaseSYNCI PEGLAABNCI PEG-L-AsparaginaseSYNCI L-Asparaginase with Polyethylene GlycolSYNCI OncasparPTNCI-GLOSSCDR0000509174 OncasparBRNCI PEG-asparaginasePTNCI-GLOSSCDR0000509190 PEG-L-Asparaginase (Enzon - Kyowa Hakko)SYDTPNSC0644954 PEGASPARGASEPTFDA7D96IR0PPM
DEFINITION	A complex of polyethylene glycol conjugated with L-asparaginase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle. The agent also induces apoptosis in tumor cells. Pegylation decreases the enzyme's antigenicity. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. (NCI04)NCI
code	C1200
sameAs	PEGASPARGASE PEGASPARGASE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0125979
is someValuesFrom of	nodeID://b647310 nodeID://b662265 nodeID://b662307 nodeID://b662317 nodeID://b662404 nodeID://b662421 nodeID://b662443 nodeID://b662536 nodeID://b662542 nodeID://b662563 nodeID://b662651 nodeID://b663319 nodeID://b663571 nodeID://b663883 nodeID://b663959 nodeID://b663969 nodeID://b664008 nodeID://b664039 nodeID://b664165 nodeID://b664378 nodeID://b664381 nodeID://b664419 nodeID://b666029 nodeID://b666056 nodeID://b666059 nodeID://b666451 nodeID://b666457 nodeID://b666466 nodeID://b666504 nodeID://b666507 nodeID://b666548 nodeID://b666552 nodeID://b666573 nodeID://b666586 nodeID://b666627 nodeID://b666631 nodeID://b667574 nodeID://b667618 nodeID://b667660 nodeID://b692925 nodeID://b692928 nodeID://b702217 nodeID://b702221
is sameAs of	PEGASPARGASE PEGASPARGASE PEGASPARGASE

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