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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pimonidazole
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Pimonidazole
NSC_Code
  • 380540
UMLS_CUI
  • C0071072
CAS_Registry
  • 70132-51-3
FDA_UNII_Code
  • 46JO4D76R2
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 40356
PDQ_Closed_Trial_Search_ID
  • 40356
Chemical_Formula
  • C11H18N4O3
Legacy_Concept_Name
  • Pimonidazole
FULL_SYN
  • PIMONIDAZOLEPTFDA46JO4D76R2
  • 1-piperidineethanol, alpha-((2-nitro-1h-imidazol-1-yl)methyl)-SNNCI
  • PimonidazoleSYDTPNSC0380540
  • PimonidazolePTNCI
  • PD 126675CNNCI
  • Ro 03-8799CNNCI
DEFINITION
  • A 2-nitroimidazole with hypoxic selectivity and potential radiosensitizing activities. Pimonidazole is reduced in hypoxic environments such as those found in tumors. In hypoxic cells, reduced pimonidazole binds to thiol-containing proteins. The resulting complexes accumulate in hypoxic tumors, thereby depleting radioprotective thiol compounds and sensitizing tumor cells to be more susceptible for radiation treatment.NCI
code
  • C1196
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