About: MUC1-KLH Vaccine/QS21     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • MUC1-KLH Vaccine/QS21
rdfs:subClassOf
Semantic_Type
  • Therapeutic or Preventive Procedure
Preferred_Name
  • MUC1-KLH Vaccine/QS21
NCI_META_CUI
  • CL371922
PDQ_Open_Trial_Search_ID
  • 38033
PDQ_Closed_Trial_Search_ID
  • 38033
Legacy_Concept_Name
  • MUC-1-KLH-Vaccine_QS21
FULL_SYN
  • MUC1-KLH Vaccine/QS21PTNCI
DEFINITION
  • A peptide vaccine containing the human tumor-associated antigen epithelial mucin (MUC1 antigen) conjugated with keyhole limpet hemocyanin (KLH) and combined with the nonspecific immunoadjuvant QS21, with potential antineoplastic activity. MUC1 antigen is linked with KLH, an immunostimulant and a hapten carrier, in order to enhance immune recognition; the co-administration of saponin-derived QS21 potentially amplifies the total immune response to the MUC1 antigen. Administration of MUC1-KLH vaccine/QS21 may result in both the production of antitumor antibodies and the stimulation of a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the MUC1 antigen. MUC1 antigen, a membrane-bound glycoprotein expressed by most glandular and ductal epithelial cells, is overexpressed as an aberrant or deglycosylated form in various cancers such as breast, prostate and ovarian cancers.NCI
code
  • C11845
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