About: Oxaliplatin

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Attributes	Values
rdf:type	Class
rdfs:label	Oxaliplatin
rdfs:subClassOf	Platinum Compounds nodeID://b698574 nodeID://b698575 nodeID://b698576 nodeID://b698577
Has_Target	DNA
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Oxaliplatin
NSC_Code	266046
UMLS_CUI	C0069717
CAS_Registry	61825-94-3
Accepted_Therapeutic_Use_For	Metastatic colorectal cancer; ovarian cancer
In_Clinical_Trial_For	Liver metastases; medulloblastoma; non-small cell lung cancer; ovarian epithelial cancer; pancreatic cancer; small bowel adenocarcinoma; supratentorial primitive neuroectodermal tumor; unspecified solid tumors Atypical teratoid rhabdoid tumor; cervical cancer; colorectal cancer; endometrial cancer; esophageal cancer; gastric cancer; gastroesophageal junction adenocarcinoma; glioblastoma multiforme
FDA_UNII_Code	04ZR38536J
Contributing_Source	FDA
ALT_DEFINITION	A drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42374
PDQ_Closed_Trial_Search_ID	42374
Chemical_Formula	C8H14N2O4Pt
Legacy_Concept_Name	Oxaliplatin
CHEBI_ID	CHEBI:31941
FULL_SYN	OxaliplatinSYDTPNSC0266046 oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)SNNCI trans-l diaminocyclohexane oxalatoplatinumSNNCI OxaliplatinPTNCI 1-OHPSYDTPNSC0266046 [SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinumSNNCI Diaminocyclohexane OxalatoplatinumSYNCI oxaliplatinPTNCI-GLOSSCDR0000045465 OxalatoplatinSYNCI OxalatoplatinSYDTPNSC0266046 DACPLATSYDTPNSC0266046 oxalato (1R,2R-cyclohexanediamine)platinum(II)SNNCI [(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinumSNNCI OxalatoplatinumSYNCI RP 54780SYDTPNSC0266046 ELOXATINSYDTPNSC0266046 JM-83CNNCI 1-OHPABNCI OxalatoplatinumSYDTPNSC0266046 trans-l DACH oxalatoplatinumSNNCI DacplatFBNCI DacotinFBNCI RP-54780CNNCI SR-96669CNNCI EloxatinPTNCI-GLOSSCDR0000413944 EloxatinBRNCI OXALIPLATINPTFDA04ZR38536J EloxatineFBNCI
DEFINITION	An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. (NCI04)NCI
code	C1181
sameAs	OXALIPLATIN OXALIPLATIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0095550
is someValuesFrom of	nodeID://b650299 nodeID://b650344 nodeID://b651489 nodeID://b652361 nodeID://b652362 nodeID://b656633 nodeID://b656642 nodeID://b656650 nodeID://b658252 nodeID://b658702 nodeID://b667187 nodeID://b670287 nodeID://b670737 nodeID://b672462 nodeID://b672468 nodeID://b672471 nodeID://b673719 nodeID://b673830 nodeID://b673842 nodeID://b673988 nodeID://b673990 nodeID://b673993 nodeID://b673997 nodeID://b674002 nodeID://b674004 nodeID://b674121 nodeID://b674163 nodeID://b676615 nodeID://b676658 nodeID://b676698 nodeID://b684382 nodeID://b698579 nodeID://b698581 nodeID://b698583 nodeID://b723753
is sameAs of	OXALIPLATIN OXALIPLATIN OXALIPLATIN

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