About: Omacetaxine Mepesuccinate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Omacetaxine Mepesuccinate
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Omacetaxine Mepesuccinate
NSC_Code
  • 141633
UMLS_CUI
  • C0062941
CAS_Registry
  • 26833-87-4
In_Clinical_Trial_For
  • Accelerated phase or blastic phase chronic myelogenous leukemia; refractory acute promyelocytic leukemia
FDA_UNII_Code
  • 6FG8041S5B
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug that belongs to the plant alkaloid family of drugs.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39476
PDQ_Closed_Trial_Search_ID
  • 39476
Chemical_Formula
  • C29H39NO9
Legacy_Concept_Name
  • Homoharringtonine
FULL_SYN
  • homoharringtoninePTNCI-GLOSSCDR0000045216
  • Omacetaxine MepesuccinatePTNCI
  • Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester), [3(R)]- (9CI)SNNCI
  • HHTABNCI
  • Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)SNNCI
  • Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI)SYDTPNSC0141633
  • OMACETAXINE MEPESUCCINATEPTFDA6FG8041S5B
  • CGX-635CNNCI
  • CeflatoninBRNCI
DEFINITION
  • A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types.NCI
code
  • C1127
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