About: Halofuginone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Halofuginone
equivalentClass
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Halofuginone
UMLS_CUI
  • C0062095
CAS_Registry
  • 55837-20-2
FDA_UNII_Code
  • L31MM1385E
Contributing_Source
  • FDA
Chemical_Formula
  • C16H17BrClN3O3
Legacy_Concept_Name
  • Halofuginone
FULL_SYN
  • HALOFUGINONEPTFDAL31MM1385E
  • HalofuginoneSYDTPNSC0713205
  • HalofuginonePTNCI
  • trans-(+/-)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinoneSNNCI
DEFINITION
  • An orally-active quinazolinone alkaloid with potential antineoplastic activity. Halofuginone interferes with the signaling pathway of transforming growth factor beta (TGF beta) and inhibits expression of matrix metalloproteinase 2, thereby inhibiting collagen type I synthesis and inducing extracellular matrix degradation, resulting in inhibition of angiogenesis, tumor growth, or metastasis.NCI
code
  • C1120
http://linked.open...y/mesh/hasConcept
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