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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fotemustine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Fotemustine
UMLS_CUI
  • C0060696
CAS_Registry
  • 92118-27-9
In_Clinical_Trial_For
  • advanced malignant melanoma; advanced gastric cancer; advanced soft tissue sarcoma; refractory brain tumor.
FDA_UNII_Code
  • GQ7JL9P5I2
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38865
PDQ_Closed_Trial_Search_ID
  • 38865
Chemical_Formula
  • C9H19ClN3O5P
Legacy_Concept_Name
  • Fotemustine
FULL_SYN
  • FotemustinePTNCI
  • diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonateSNNCI
  • 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl esterSNNCI
  • fotemustinePTNCI-GLOSSCDR0000439437
  • S 10036CNNCI
  • MuphoranFBNCI
  • FOTEMUSTINEPTFDAGQ7JL9P5I2
  • [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl esterSNNCI
DEFINITION
  • A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.NCI
code
  • C1106
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