About: Fludrocortisone Acetate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fludrocortisone Acetate
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Fludrocortisone Acetate
NSC_Code
  • 15186
UMLS_CUI
  • C0616274
CAS_Registry
  • 514-36-3
FDA_UNII_Code
  • V47IF0PVH4
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39243
PDQ_Closed_Trial_Search_ID
  • 39243
Chemical_Formula
  • C23H31FO6
Legacy_Concept_Name
  • Fludrocortisone
FULL_SYN
  • Fludrocortisone AcetatePTNCI
  • FLUDROCORTISONE ACETATEPTFDAV47IF0PVH4
  • Florinef AcetateSYNCI
  • Florinef acetateSYDTPNSC0015186
  • Fludrocortisone acetateSYDTPNSC0015186
  • FlorinefBRNCI
DEFINITION
  • The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.NCI
code
  • C1103
sameAs
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