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AttributesValues
rdf:type
rdfs:label
  • Fenretinide
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Fenretinide
NSC_Code
  • 374551
UMLS_CUI
  • C0060197
CAS_Registry
  • 65646-68-6
In_Clinical_Trial_For
  • Chemoprevention for patients at increased risk for ovarian cancer; recurrent or resistant neuroblastoma; advanced or metastatic hormone-refractory prostate cancer
  • Chemoprevention of recurrent superficial bladder cancer; recurrent or metastatic ovarian epithelial or primary peritoneal cancer; recurrent glioblastoma multiforme; advanced solid tumors
FDA_UNII_Code
  • 187EJ7QEXL
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39582
PDQ_Closed_Trial_Search_ID
  • 39582
Chemical_Formula
  • C26H33NO2
Legacy_Concept_Name
  • Fenretinide
CHEBI_ID
  • CHEBI:42588
FULL_SYN
  • FenretinideSYDTPNSC0374551
  • FenretinidePTNCI
  • 4-(all-trans-retino-yl)aminophenolSNNCI
  • all-trans-N-4'-hydroxyretinanilideSNNCI
  • fenretinidePTNCI-GLOSSCDR0000045233
  • FenretinimideSYNCI
  • FenretinidePTDCP00056
  • 4-HydroxyphenylretinamideSNNCI
  • N-(4-hydroxyphenyl)retinamideSYDTPNSC0374551
  • 4-HPRABNCI
  • HPR-4ABNCI
  • all-trans-N-(4-Hydroxyphenyl)retinamideSNNCI
  • N-(4-hydroxyphenyl)retinamideSNNCI
  • FENRETINIDEPTFDA187EJ7QEXL
  • McN-R-1967CNNCI
  • all-trans-4'-hydroxyretinanilideSYDTPNSC0374551
  • All-trans-4'-HydroxyretinanilideSNNCI
DEFINITION
  • An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04)NCI
code
  • C1098
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