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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Iproplatin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Iproplatin
NSC_Code
  • 256927
UMLS_CUI
  • C0057856
CAS_Registry
  • 62928-11-4
  • 83291-20-7
FDA_UNII_Code
  • 5R9F9NE9Z2
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39183
PDQ_Closed_Trial_Search_ID
  • 39183
Chemical_Formula
  • 2C3H9N.2Cl.Pt.2HO
Legacy_Concept_Name
  • Iproplatin
FULL_SYN
  • (OC-6-33)-dichlorodihydroxybis(2-propanamine)platinumSNNCI
  • Diisopropylammine-trans-dihydroxymalonatoplatinum(IV)SNNCI
  • JM-9CNNCI
  • CHIPABNCI
  • IPROPLATINPTFDA5R9F9NE9Z2
  • Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)-SYDTPNSC0256927
  • IproplatinPTNCI
DEFINITION
  • A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04)NCI
code
  • C1070
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