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AttributesValues
rdf:type
rdfs:label
  • Defibrotide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Defibrotide
UMLS_CUI
  • C0057257
CAS_Registry
  • 83712-60-1
Accepted_Therapeutic_Use_For
  • Thrombotic thrombocytopenic purpura
In_Clinical_Trial_For
  • Liver damage following peripheral stem cell transplantation
FDA_UNII_Code
  • 438HCF2X0M
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug under study for the prevention of veno-occlusive disease, a rare complication of high-dose chemotherapy and stem cell transplantation in which small veins in the liver become blocked.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43522
PDQ_Closed_Trial_Search_ID
  • 43522
Legacy_Concept_Name
  • Defibrotide
FULL_SYN
  • DefibrotidePTNCI
  • defibrotidePTNCI-GLOSSCDR0000046709
  • DefibrinotideSYNCI
  • NoravidBRNCI
  • DEFIBROTIDE (BOVINE)PTFDA438HCF2X0M
  • Fraction PSYNCI
  • ProciclideSYNCI
DEFINITION
  • A polydeoxyribonucleotide with antithrombotic, thrombolytic, and fibrinolytic properties. Defibrotide induces the release of prostaglandin 12 and reduces the expression of adhesion molecules on endothelial cells, thereby interfering with platelet and leukocyte adhesion to the endothelium. (NCI04)NCI
code
  • C1064
http://linked.open...y/mesh/hasConcept
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