About: Chlorozotocin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Chlorozotocin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Chlorozotocin
NSC_Code
  • 178248
UMLS_CUI
  • C0055465
CAS_Registry
  • 54749-90-5
FDA_UNII_Code
  • 3053LTY75Z
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39182
PDQ_Closed_Trial_Search_ID
  • 39182
Chemical_Formula
  • C9H16ClN3O7
Legacy_Concept_Name
  • Chlorozotocin
FULL_SYN
  • DCNUSYDTPNSC0178248
  • CHLOROZOTOCINPTFDA3053LTY75Z
  • ChlorozotocinPTNCI
  • ChlorozotocinSYDTPNSC0178248
  • ChlorozotocynaSYNCI
  • CZTABNCI
  • D-GlucopyranoseSNNCI
  • DCNUABNCI
  • CHLZABNCI
  • D-glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxySNNCI
  • D-glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)SNNCI
  • 2-[[[(2-chloroethyl)nitrosamino]carbonyl]amino]-2-deoxy-D-glucoseSNNCI
  • D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)SYDTPNSC0178248
  • 1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)ureaSNNCI
  • D-Glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-SYDTPNSC0178248
  • 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranoseSNNCI
DEFINITION
  • A glucose-linked chloroethylnitrosourea with potential antineoplastic activity. Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death. This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models. Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. (NCI04)NCI
code
  • C1049
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