About: Recombinant Adenovirus-Interferon/Syn3     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Recombinant Adenovirus-Interferon/Syn3
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Adenovirus-Interferon/Syn3
PDQ_Open_Trial_Search_ID
  • 746097
PDQ_Closed_Trial_Search_ID
  • 746097
FULL_SYN
  • InstiladrinFBNCI
  • rAd-IFN/Syn3ABNCI
  • Recombinant Adenovirus-Interferon With Syn3SYNCI
  • Recombinant Adenovirus-Interferon/Syn3PTNCI
DEFINITION
  • A non-replicating recombinant adenovirus type 5 (Ad5)-vector encoding the gene for interferon alpha-2b (IFN alpha-2b) and the gene transfer enhancement agent Syn 3, with potential antineoplastic activity. Upon intravesical administration, recombinant adenovirus-interferon with Syn3 transfects both cancerous and normal bladder cells, and the adenovirus secretes interferon (IFN alpha-2b) into the bladder. IFN exerts a direct antitumor killing effect and a bystander effect, thereby killing adjacent, non-transfected cancerous bladder cells. Syn 3 enhances the ability of the adenoviral vector to transfect cells.NCI
code
  • C104743
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software