About: WT1 235-243 Peptide Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • WT1 235-243 Peptide Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • WT1 235-243 Peptide Vaccine
PDQ_Open_Trial_Search_ID
  • 746008
PDQ_Closed_Trial_Search_ID
  • 746008
FULL_SYN
  • WT1 235-243 Peptide VaccinePTNCI
DEFINITION
  • A synthetic peptide vaccine consisting of a HLA-A24-restricted human Wilms' Tumor protein-1 (WT1) peptide comprised of amino acids 235 through 243, a MHC class I-restricted peptide, with potential immunomodulating and antitumor activities. Vaccination with WT1 235-243 peptide may induce a WT1-specific cytotoxic T-lymphocyte (CTL) response against WT1 expressing cells, resulting in cell lysis and inhibition of cancer cell proliferation. WT1, a zinc finger DNA-binding protein, is overexpressed in most types of leukemia and in a variety of solid cancers.NCI
code
  • C104734
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