About: Autologous GM-CSF-Secreting Lethally Irradiated Leukemia Cell Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Autologous GM-CSF-Secreting Lethally Irradiated Leukemia Cell Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Autologous GM-CSF-Secreting Lethally Irradiated Leukemia Cell Vaccine
PDQ_Open_Trial_Search_ID
  • 745656
PDQ_Closed_Trial_Search_ID
  • 745656
FULL_SYN
  • GVAX Leukemia VaccineSYNCI
  • Autologous GM-CSF-Secreting Lethally Irradiated Leukemia Cell VaccinePTNCI
DEFINITION
  • An autologous cancer vaccine composed of lethally irradiated leukemia cells that are genetically modified to secrete the immunostimulatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential immunostimulating and antineoplastic activities. Upon intradermal injection, the autologous GM-CSF-secreting lethally irradiated leukemia cell vaccine secretes GM-CSF. In turn, GM-CSF may stimulate the immune system to attack tumor cells by enhancing the activation of dendritic cells (DCs) and promoting antigen presentation to both B- and T-lymphocytes. In addition, GM-CSF promotes antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function.NCI
code
  • C104419
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