About: Topical Cocaine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Topical Cocaine Hydrochloride
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Topical Cocaine Hydrochloride
NCI_META_CUI
  • CL438387
PDQ_Open_Trial_Search_ID
  • 744401
PDQ_Closed_Trial_Search_ID
  • 744401
FULL_SYN
  • Topical Cocaine HydrochloridePTNCI
DEFINITION
  • A topical formulation of the hydrochloride salt of the tropane alkaloid cocaine, with local anesthetic activity. Upon topical application of the cocaine hydrochloride solution to nasal mucous membranes, cocaine reversibly binds to and blocks the voltage-gated sodium channels in the neuronal cell membranes. By stabilizing neuronal membranes, cocaine inhibits the initiation and conduction of nerve impulses and produces a reversible loss of sensation.NCI
code
  • C104004
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