About: Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet

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Attributes	Values
rdf:type	Class
rdfs:label	Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet
rdfs:subClassOf	Opioid Agonist Opiate Antagonist
Semantic_Type	Pharmacologic Substance
Preferred_Name	Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet
UMLS_CUI	C3180499
PDQ_Open_Trial_Search_ID	742626
PDQ_Closed_Trial_Search_ID	742626
FULL_SYN	Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release TabletPTNCI TarginFBNCI TarginactFBNCI
DEFINITION	A prolonged-release tablet formulation composed of the hydrochloride salt form of the opioid receptor agonist oxycodone and the hydrochloride salt form of the opioid receptor antagonist naloxone which may produce analgesia while relieving opioid-mediated gastrointestinal (GI) side effects. Upon oral administration, oxycodone binds to opioid receptors, thereby mimicking the effects of endogenous opiates to provide analgesia. As naloxone is very poorly absorbed, this agent binds locally to opiate receptors in the GI tract, thereby preventing oxycodone from binding to these receptors. This relieves the opioid-related side effects on the GI tract, including opioid-induced constipation.NCI
code	C103824

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