About: PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94
NCI_META_CUI
  • CL437434
PDQ_Open_Trial_Search_ID
  • 740819
PDQ_Closed_Trial_Search_ID
  • 740819
FULL_SYN
  • PEG-linked L-RNA Oligonucleotide Hepcidin-targeting Agent NOX-H94PTNCI
  • NOX-H94CNNCI
DEFINITION
  • A proprietary 44-nucleotide L-stereoisomer RNA oligonucleotide conjugated to a 40 kDa polyethylene glycol (PEG) that targets hepcidin with potential anti-anemic activity. Upon intravenous or subcutaneous administration, PEG-linked L-RNA oligonucleotide hepcidin targeting agent NOX-H94 binds to hepcidin and prevents it from binding to the iron channel ferroportin, located on the basolateral surface of gastrointestinal enterocytes and the plasma membrane of macrophages. This prevents hepcidin-induced internalization and degradation of ferroportin, thus decreasing macrophage iron retention. In turn, binding of NOX-H94 to hepcidin normalizes plasma iron levels and increases erythropoiesis. This may inhibit anemia caused by inflammation. Hepcidin, a peptide hormone that plays a key role in the homeostasis of systemic iron, is upregulated during acute and chronic inflammation in response to cytokines. The unique mirror-image configuration of this agent renders it resistant to hydrolysis and shows a low antigenicity profile. Pegylation increases the half-life of this agent.NCI
code
  • C103195
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