About: 3-Chlorotyrosine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • 3-Chlorotyrosine
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Chemical Viewed Structurally
Preferred_Name
  • 3-Chlorotyrosine
UMLS_CUI
  • C0254781
FULL_SYN
  • L-(8CI)-3-Chloro-TyrosineSYNCI
  • ChlorotyrosineSYNCI
  • 3-ChlorotyrosinePTNCI
  • Cl-TyrABNCI
  • MonochlorotyrosineSYNCI
  • 3-Chloro-L-TyrosineSYNCI
DEFINITION
  • A specific biomarker of hypochlorous acid (HClO), the oxidation product of myeloperoxidase (MPO). Under oxidative stress, 3-chlorotyrosine is produced in proteins with tyrosine residues by the strong oxidant HClO. HClO which is formed at sites of inflammation is also the anti-bacterial molecule produced by neutrophils through MPO-catalyzed oxidation. MPO is a heme-containing enzyme secreted by activated neutrophils and monocytes; it is the only enzyme that produces HClO. Therefore, 3-chlorotyrosine can potentially be used to help determine the extent of neutrophilic inflammation.NCI
code
  • C103150
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