About: hTERT/Survivin/CMV Multipeptide Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • hTERT/Survivin/CMV Multipeptide Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • hTERT/Survivin/CMV Multipeptide Vaccine
NCI_META_CUI
  • CL437182
PDQ_Open_Trial_Search_ID
  • 738632
PDQ_Closed_Trial_Search_ID
  • 738632
FULL_SYN
  • hTERT/Survivin/CMV Multipeptide VaccinePTNCI
DEFINITION
  • A vaccine containing multiple peptides derived from the human telomerase reverse transcriptase (hTERT), survivin and cytomegalovirus (CMV), with potential immunostimulating and antineoplastic activities. Upon administration, hTERT/survivin/CMV multipeptide vaccine may elicit a cytotoxic T cell (CTL) response against tumor cells espressing hTERT, survivin and CMV. hTERT, the catalytic subunit of telomerase, and the inhibitor of apoptosis (IAP) family member survivin, both often upregulated in tumor cells, play key roles in tumor cell growth and survival. Further, CMV expression is correlated with certain types of cancer.NCI
code
  • C102879
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