About: CK2-targeting Synthetic Peptide CIGB-300

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Attributes	Values
rdf:type	Class
rdfs:label	CK2-targeting Synthetic Peptide CIGB-300
rdfs:subClassOf	ANTINEOPLASTICS
Semantic_Type	Pharmacologic Substance
Preferred_Name	CK2-targeting Synthetic Peptide CIGB-300
UMLS_CUI	C2605865
PDQ_Open_Trial_Search_ID	737263
PDQ_Closed_Trial_Search_ID	737263
FULL_SYN	P15-tatCNNCI CK2-targeting Synthetic Peptide CIGB-300PTNCI CIGB-300CNNCI
DEFINITION	A synthetic peptide targeting the substrates of casein kinase 2 (CK2), with potential antineoplastic activity. Upon administration and nucleolar localization, CK2-targeting synthetic peptide CIGB-300 binds to phosphoacceptor sites on the CK2 substrates, in particular the oncoprotein nucleophosmin (B23 or NPM1). This blocks the activation of B23 and induces apoptosis, thereby inhibiting tumor cell growth in susceptible tumor cells. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. Overexpression of B23 has been correlated with increased cellular growth and proliferation as well as inhibition of differentiation and apoptosis.NCI
code	C102849
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0526194

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