About: Carmustine Sustained-Release Implant Wafer     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Carmustine Sustained-Release Implant Wafer
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Carmustine Sustained-Release Implant Wafer
NCI_META_CUI
  • CL437131
PDQ_Open_Trial_Search_ID
  • 737196
PDQ_Closed_Trial_Search_ID
  • 737196
FULL_SYN
  • Carmustine Sustained-Release Implant WaferPTNCI
  • CASANT WaferFBNCI
DEFINITION
  • A sustained release (SR) implant wafer containing the lipophilic nitrosourea carmustine (BCNU) with antineoplastic activity. Upon intracranial administration of the implant wafer and subsequent release of BCNU from the wafer, this agent alkylates and cross-links DNA during all phases of the cell cycle, resulting in the disruption of DNA function, cell cycle arrest, and apoptosis. This wafer contains the biodegradable copolymer PLGA (poly(lactide-co-glycolide) as the major drug delivery vehicle which is slowly degraded into water and carbon dioxide thereby continously releasing BCNU over approximately 3-4 weeks. Compared to systemic administration of BCNU alone, this local SR formulation is able to maintain higher drug concentrations locally over a longer period of time while minimizing exposure to other tissues.NCI
code
  • C102847
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