About: Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650

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About: Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650 Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650
rdfs:subClassOf	Radioimmunoconjugate
Semantic_Type	Pharmacologic Substance
Preferred_Name	Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650
NCI_META_CUI	CL437023
PDQ_Open_Trial_Search_ID	736553
PDQ_Closed_Trial_Search_ID	736553
FULL_SYN	I-124 PGN650ABNCI I-124 Anti-PS MoAb PNG650SYNCI Iodine I 124 Anti-phosphatidylserine Monoclonal Antibody PGN650PTNCI
DEFINITION	A radioimmunoconjugate composed of the F(ab')2 fragment of human monoclonal antibody PGN650 against phosphatidylserine (PS) labeled with the radioisotope iodine I 124, with potential imaging activity upon positron-emission tomography (PET). Upon administration, the MoAb moiety of PGN650 binds to exposed PS on tumor cells, thereby allowing for the visualization of tumors upon PET. This may facilitate the assessment of the effectiveness of antitumor agents. The phospholipid PS is normally located on the inner leaflet of the plasma membrane of healthy cells but is flipped to the outer leaflet in the endothelial lining of the tumor vasculature and other tumor cells in response to chemo- or radio- treatments in addition to oxidative stress.NCI
code	C102785

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