About: Heparan Sulfate Glycosaminoglycan Mimetic M402     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Heparan Sulfate Glycosaminoglycan Mimetic M402
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Heparan Sulfate Glycosaminoglycan Mimetic M402
NCI_META_CUI
  • CL437006
PDQ_Open_Trial_Search_ID
  • 735811
PDQ_Closed_Trial_Search_ID
  • 735811
FULL_SYN
  • Heparan Sulfate Glycosaminoglycan Mimetic M402PTNCI
  • M402CNNCI
  • HSGAG Mimetic M402SYNCI
DEFINITION
  • A low molecular weight heparin derivative and heparan sulfate proteoglycan (HSPG) mimetic with no or minimal anticoagulant activity and potential antineoplastic activities. Upon administration, M402 mimics HSPGs by binding to and inhibiting various heparin-binding growth factors, chemokines, and cytokines such as VEGF, HGF, FGF2, SDF-1a, heparanase and P-selectin all of which are essential for tumor angiogenesis and metastasis to occur. This inhibits heparin binding growth factor-mediated signaling and disrupts tumor-stromal interactions eventually leading to an inhibition of angiogenesis and tumor cell progression. In addition, M402 may enhance the cytotoxic effect of other chemotherapeutic agents.NCI
code
  • C102749
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