About: Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract Granules     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract Granules
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract Granules
NCI_META_CUI
  • CL437005
PDQ_Open_Trial_Search_ID
  • 735790
PDQ_Closed_Trial_Search_ID
  • 735790
FULL_SYN
  • V. myrtillus/M. cordata/E. angustfolia Extract GranulesSYNCI
  • Samital GranulesFBNCI
  • Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract GranulesPTNCI
DEFINITION
  • A proprietary suspension formulation prepared from granules of standardized extracts from the fruits of Vaccinium myrtillus, the aerial parts of Macleaya cordata and the roots of Echinacea angustifolia, with potential anti-mucositis, anti-inflammatory, and analgesic activities. The main active ingredients of this formulation include anthocyanosides and procyanidins, benzophenanthridinic alkaloids, and alkylamides from V. myrtillus, M. cordata and E. angustifolia extracts, respectively. Upon administration in the mucosal cavity, the anthocyanosides scavenge free radicals, form a protective barrier on the mucosa, and protect the integrity of the capillary vessels; the benzophenanthridine alkaloids prevent the production of pro-inflammatory cytokines by inhibiting NF-kB and may halt the growth of microorganisms; the alkylamides inhibit cyclooxygenase and 5-lipoxygenase thereby blocking productions of prostaglandin and leukotriene. Furthermore, alkylamides modulate the expression of tumor necrosis factor alpha and other cytokines involved in inflammation processes through cannabinoid type 2 receptors and as cannabinomimetics they may also exert analgesic activity.NCI
code
  • C102748
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