About: Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Extended Release Bupivacaine Hydrochloride Resorbable Matrix Formulation
NCI_META_CUI
  • CL437002
PDQ_Open_Trial_Search_ID
  • 735755
PDQ_Closed_Trial_Search_ID
  • 735755
FULL_SYN
  • Sustained Release Bupivacaine HydrochlorideSYNCI
  • Extended Release Bupivacaine Hydrochloride Resorbable Matrix FormulationPTNCI
  • ER Bupivacaine HClSYNCI
  • SABER-Bupivacaine HydrochlorideSYNCI
DEFINITION
  • An extended release (ER) injectable formulation composed of the hydrochloride salt form of bupivacaine, an amide-type, long-acting local anesthetic, in a resorbable sucrose acetate isobutyrate-based matrix, with analgesic activity. Following administration in or around a specific site, ER bupivacaine is released from the matrix over an extended period of time. Upon release, bupivacaine reversibly binds to specific voltage-gated sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions, membrane destabilization, and depolarization inhibition thus disrupting nerve impulse conduction. This eventually leads to a reversible loss of sensation. This formulation may provide pain relief up to 72 hours.NCI
code
  • C102745
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