About: Klebsiella pneumoniae Glycoprotein     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Klebsiella pneumoniae Glycoprotein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Klebsiella pneumoniae Glycoprotein
PubMedID_Primary_Reference
  • 2662280
UMLS_CUI
  • C0892377
CAS_Registry
  • 68583-24-4
PDQ_Open_Trial_Search_ID
  • 39167
PDQ_Closed_Trial_Search_ID
  • 39167
Legacy_Concept_Name
  • Klebsiella_pneumoniae_Glycoprotein
FULL_SYN
  • Klebsiella pneumoniae GlycoproteinPTNCI
  • BiostimBRNCI
  • RU- 41740CNNCI
  • RU 41.740CNNCI
DEFINITION
  • A glycoprotein complex extracted from Klebsiella pneumoniae K2O1 strain with immunostimulating property. This glycoprotein complex consists of 2 repetitive glycoprotein subunits; P1 comes from the bacterial capsule about 95 kD in molecular mass and F1, having an lipopolysaccharide-related structure (350 kDa), is derived from bacterial external membrane. Although the mechanism of action is not fully elucidated, Klebsiella pneumoniae F1 fraction appears to suppress monocyte apoptosis, hence inducing the differentiation of monocytes into macrophages. Furthermore, this agent also enhances humoral and cell-mediated immune responses, and increases natural killer cell cytotoxicity functions. This glycoprotein has been shown to reduce the incidence of infection.NCI
code
  • C1018
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