About: Linoleyl Carbonate-paclitaxel     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Linoleyl Carbonate-paclitaxel
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Linoleyl Carbonate-paclitaxel
NCI_META_CUI
  • CL435910
PDQ_Open_Trial_Search_ID
  • 733643
PDQ_Closed_Trial_Search_ID
  • 733643
FULL_SYN
  • LOC-paclitaxelSYNCI
  • Linoleyl Carbonate-paclitaxelPTNCI
  • 2-Linoleyl Carbonate-paclitaxelSYNCI
DEFINITION
  • A formulation of the 6-omega fatty acid derivative 2'-linoleyl carbonate (LOC) conjugated to paclitaxel, a taxane compound extracted from the Pacific yew tree Taxus brevifolia, with potential antineoplastic activity. Paclitaxel binds to and stabilizes tubulin, thereby interfering with the dynamics of microtubule assembly/disassembly and resulting in the inhibition of cell division. LOC enhances the uptake of paclitaxel by tumor cells, thereby concentrating this agent in tumor cells compared to normal cells, and may decrease its toxicity profile; fatty acids serve as energy sources and biochemical precursors for the fast growing tumor cells.NCI
code
  • C101792
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