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AttributesValues
rdf:type
rdfs:label
  • Sofosbuvir
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sofosbuvir
PubMedID_Primary_Reference
  • 20845908
UMLS_CUI
  • C2976304
CAS_Registry
  • 1190307-88-0
FDA_UNII_Code
  • WJ6CA3ZU8B
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 729636
PDQ_Closed_Trial_Search_ID
  • 729636
Chemical_Formula
  • C22H29FN3O9P
FULL_SYN
  • SofosbuvirPTNCI
  • L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl EsterSNNCI
  • GS-7977CNNCI
  • PSI-7977CNNCI
  • SOFOSBUVIRPTFDAWJ6CA3ZU8B
DEFINITION
  • An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.NCI
code
  • C101263
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